Home Drug Guide Ardeparin Sodium

Drug Guide

Generic Name

Ardeparin Sodium

Brand Names Normiflo

Classification

Therapeutic: Anticoagulant (antithrombotic)

Pharmacological: Heparin-like agent; Low molecular weight heparin

FDA Approved Indications

Prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing surgery or immobilization, including confined mobility due to illness.

Mechanism of Action

Ardeparin Sodium enhances the activity of antithrombin III, which inhibits thrombin and factor Xa, leading to decreased blood clot formation.

Dosage and Administration

Adult: Dosage varies based on indication; typically administered subcutaneously or intravenously as per protocol; dose adjustments based on coagulation monitoring.

Pediatric: Use is limited; consult specific pediatric guidelines.

Geriatric: Adjust dose cautiously due to increased bleeding risk in the elderly.

Renal Impairment: Use with caution; adjust dose based on renal function and monitoring.

Hepatic Impairment: No specific adjustment; use with caution, monitor coagulation parameters.

Pharmacokinetics

Absorption: Poor oral absorption; administered parenterally.

Distribution: Limited; mainly plasma proteins.

Metabolism: Metabolized in the reticuloendothelial system and liver.

Excretion: Renal and hepatic pathways.

Half Life: Approximately 4.5 to 7 hours.

Contraindications

Known hypersensitivity to heparin or porcine products.
Active significant bleeding.
History of heparin-induced thrombocytopenia.

Precautions

Use with caution in patients with bleeding disorders, recent surgery, or traumatic injury. Monitor for signs of bleeding; use cautiously in pregnancy and lactation.

Adverse Reactions - Common

Bleeding (Common)
Thrombocytopenia (Common)

Adverse Reactions - Serious

Heparin-induced thrombocytopenia (HIT) (Serious but less common)
Severe bleeding (Serious)

Drug-Drug Interactions

Other anticoagulants, antiplatelet agents, thrombolytics.

Drug-Food Interactions

N/A

Drug-Herb Interactions

Ginkgo biloba, garlic, ginseng (may increase bleeding risk).

Nursing Implications

Assessment: Monitor for signs of bleeding, platelet counts, coagulation parameters (aPTT).

Diagnoses:

Risk for bleeding
Impaired tissue perfusion due to bleeding

Implementation: Administer as prescribed, monitor lab values and patient response.

Evaluation: Assess for bleeding complications, monitor clotting times, and adjust doses accordingly.

Patient/Family Teaching

Report signs of bleeding (bruising, hematuria, bleeding gums).
Do not take NSAIDs or other blood-thinning products without consultation.
Complete prescribed course of therapy.

Special Considerations

Black Box Warnings:

Spinal hematoma risk in patients receiving neuraxial anesthesia or lumbar puncture.

Genetic Factors: Not specifically relevant.

Lab Test Interference: May affect activated partial thromboplastin time (aPTT).

Overdose Management

Signs/Symptoms: Uncontrolled bleeding, hematomas.

Treatment: Discontinue heparin; administer protamine sulfate as an antidote for overdose.

Storage and Handling

Storage: Store at room temperature, protected from light. Refrigeration not required.

Stability: Stable for the duration of the unopened vial's shelf life.