Nurses Compass
Drug Guide
Haloprogin
Classification
Therapeutic: Antifungal
Pharmacological: Allylamine antifungal
FDA Approved Indications
- Treatment of topical fungal infections such as athlete's foot, ringworm, and candidiasis
Mechanism of Action
Haloprogin inhibits fungal enzymes involved in ergosterol synthesis, disrupting fungal cell membrane formation.
Dosage and Administration
Adult: Apply a thin layer of Halotex to affected area, usually twice daily, for the duration specified by the healthcare provider.
Pediatric: Use as directed by a pediatrician, generally similar to adult dosage.
Geriatric: Use with caution, monitor for hypersensitivity or side effects.
Renal Impairment: No specific adjustments established; caution advised.
Hepatic Impairment: No specific adjustments established; caution advised.
Pharmacokinetics
Absorption: Minimal systemic absorption when used topically.
Distribution: N/A for topical use.
Metabolism: Metabolized locally in skin tissues.
Excretion: Excreted via skin and possibly minor systemic absorption.
Half Life: Not applicable for topical application.
Contraindications
- Hypersensitivity to haloprogin or other azole antifungals.
Precautions
- Avoid contact with eyes; discontinue if irritation occurs. Not recommended for use on large open wounds.
Adverse Reactions - Common
- Skin irritation or dermatitis (Uncommon)
Adverse Reactions - Serious
- Allergic contact dermatitis or hypersensitivity reactions (Rare)
Drug-Drug Interactions
- None well documented for topical use.
Drug-Food Interactions
- None
Drug-Herb Interactions
- None established.
Nursing Implications
Assessment: Assess site of application for initial skin condition and monitor for adverse reactions.
Diagnoses:
- Impaired skin integrity related to dermatophyte infection.
Implementation: Apply as prescribed, ensure proper skin cleaning before application.
Evaluation: Monitor lesion improvement and for potential adverse effects.
Patient/Family Teaching
- Apply medication as directed, usually twice daily.
- Keep the affected area clean and dry.
- Report any signs of allergic reaction or severe irritation.
- Avoid contact with eyes and mucous membranes.
Special Considerations
Black Box Warnings:
- None.
Genetic Factors: None known.
Lab Test Interference: None.
Overdose Management
Signs/Symptoms: Overuse may lead to localized irritation.
Treatment: Discontinue use, symptomatic treatment as needed.
Storage and Handling
Storage: Store at room temperature, away from heat and moisture.
Stability: Stable under recommended conditions.