Home Drug Guide Ibalizumab-uiyk

Drug Guide

Generic Name

Ibalizumab-uiyk

Brand Names Trogarzo

Classification

Therapeutic: Antiretroviral Agent for HIV Infection

Pharmacological: Monoclonal Antibody

FDA Approved Indications

  • Treatment of Multi-Drug Resistant HIV-1 Infection in adults when other treatment options have failed

Mechanism of Action

Ibalizumab-uiyk is a humanized monoclonal antibody that binds to the CD4 receptor on T-cells, blocking HIV-1 from entering and infecting the cells, thereby preventing viral replication.

Dosage and Administration

Adult: 800 mg IV loading dose at week 1, then 800 mg every 2 weeks as maintenance dose

Pediatric: Not established

Geriatric: No specific dosage adjustment; monitor carefully

Renal Impairment: No dosage adjustment needed for renal impairment

Hepatic Impairment: No specific data; use caution and monitor closely

Pharmacokinetics

Absorption: Administered intravenously, so absorption is complete and immediate

Distribution: Widely distributed in body tissues; details not fully defined

Metabolism: Metabolized via typical protein degradation pathways, not through hepatic enzymes

Excretion: Primarily via proteolytic catabolism, not renal or hepatic pathways

Half Life: Approximately 3 days (72 hours)

Contraindications

  • Known hypersensitivity to ibalizumab-uiyk or any component

Precautions

  • Use with caution in patients with known hypersensitivity reactions; monitor for infusion-related reactions and hypersensitivity. Consider the potential for immune-mediated reactions.

Adverse Reactions - Common

  • Diarrhea (Unknown)
  • Nausea (Unknown)
  • Rash (Unknown)

Adverse Reactions - Serious

  • Infusion-related reactions (allergic reactions, hypersensitivity) (Rare)
  • Immune-mediated events, including hypersensitivity reactions (Rare)

Drug-Drug Interactions

  • No significant interactions reported, but caution with other immunomodulating agents

Drug-Food Interactions

  • No relevant interactions established

Drug-Herb Interactions

  • No data available

Nursing Implications

Assessment: Monitor for infusion-related reactions during and after administration; assess for signs of hypersensitivity; monitor viral load and CD4 counts periodically.

Diagnoses:

  • Risk for allergic reaction or infusion reaction
  • Impaired immunity

Implementation: Administer IV infusion slowly according to prescribed rate; prepare emergency equipment for hypersensitivity reactions; observe patient closely during and after infusion.

Evaluation: Evaluate viral load response and CD4 counts; monitor for adverse reactions and infusion site reactions.

Patient/Family Teaching

  • Report any symptoms of allergic or infusion reactions immediately.
  • Educate about the importance of adherence to therapy and follow-up visits.
  • Inform about possible side effects and when to seek medical attention.

Special Considerations

Black Box Warnings:

  • Infusion-related hypersensitivity reactions, including anaphylaxis, have been reported; patients should be observed closely during and after infusion.
  • Potential for immune-mediated adverse reactions.

Genetic Factors: None established.

Lab Test Interference: No known interference with routine laboratory tests.

Overdose Management

Signs/Symptoms: Infusion reactions, hypersensitivity

Treatment: Discontinue infusion immediately; provide supportive care; manage symptoms of hypersensitivity or allergic reactions as per standard protocols.

Storage and Handling

Storage: Store vials at 2°C to 8°C (36°F to 46°F); keep in original carton to protect from light.

Stability: Stable up to the expiration date when stored properly.

🛡️ 5 Critical Medication Safety Tips for Nurses

1

Triple-Check High-Risk Medications

Always have another nurse verify insulin, heparin, warfarin, and chemotherapy drugs. These "high-alert" medications cause the most serious errors. Check concentration, dose calculation, and pump settings twice.

2

Know Look-Alike, Sound-Alike Drugs

Common mix-ups: hydromorphone/morphine, Celebrex/Celexa, Zyprexa/Zyrtec. Always use BOTH generic and brand names, read labels twice, and use barcode scanning when available. One wrong letter can be fatal.

3

Assess Before AND After Giving Meds

Check vitals before cardiac meds, pain levels before analgesics, and blood glucose before insulin. Always reassess within 30 minutes to evaluate effectiveness and watch for adverse reactions.

4

Watch for Drug Interactions

Common dangerous combinations: warfarin + aspirin (bleeding), ACE inhibitors + potassium (hyperkalemia), digoxin + diuretics (toxicity). Always check drug interactions before administering new medications.

5

Educate Your Patients

Teach patients medication names, purposes, major side effects, and what to report. Informed patients catch errors and improve compliance. Always encourage questions - an educated patient is a safer patient.

⚡ Remember: When in doubt, don't give it out! It's always safer to double-check than regret later.

⚠️ Medical Disclaimer

This drug guide is for educational purposes only and is NOT intended for clinical use. Always consult current prescribing information, healthcare providers, and institutional protocols before administering any medication. Do not use this information for patient care decisions.