Home Drug Guide Ibrexafungerp citrate

Drug Guide

Generic Name

Ibrexafungerp citrate

Brand Names Brexafemme

Classification

Therapeutic: Antifungal

Pharmacological: Glucan synthase inhibitor

FDA Approved Indications

  • Vaginal yeast infections (Vulvovaginal candidiasis)

Mechanism of Action

Ibrexafungerp inhibits 1,3-β-D-glucan synthase, an enzyme essential for fungal cell wall synthesis, leading to cell wall disruption and fungal cell death.

Dosage and Administration

Adult: Check the specific dosing regimen as per FDA approval; typically, a 300 mg dose taken orally once daily for 3 days.

Pediatric: Not currently approved for pediatric use.

Geriatric: Adjust if renal or hepatic impairment present; no specific dose adjustment recommended but monitor closely.

Renal Impairment: No specific adjustment necessary, but monitor for adverse effects.

Hepatic Impairment: Use with caution; no specific dosage adjustments established.

Pharmacokinetics

Absorption: Well absorbed orally.

Distribution: Widely distributed; specifics not fully detailed.

Metabolism: Metabolized minimally, primarily by hepatic pathways.

Excretion: Excreted in feces and urine.

Half Life: Approximately 16 hours.

Contraindications

  • Hypersensitivity to Ibrexafungerp or its components.

Precautions

  • Use with caution in patients with hepatic impairment; monitor liver function tests.
  • Limited data in pregnancy and lactation; use only if potential benefit justifies potential risk.

Adverse Reactions - Common

  • Nausea (Common)
  • Diarrhea (Common)
  • Headache (Common)

Adverse Reactions - Serious

  • Liver enzyme elevations (ALT, AST) (Uncommon)
  • Allergic reactions including rash, hypersensitivity (Rare)

Drug-Drug Interactions

  • Potential interactions with medications affecting CYP enzymes; consult detailed prescribing information.

Drug-Food Interactions

  • None specific.

Drug-Herb Interactions

  • Avoid concomitant use with herbal products that affect CYP pathways.

Nursing Implications

Assessment: Monitor for signs of hepatic dysfunction and hypersensitivity.

Diagnoses:

  • Risk for hepatic injury
  • Risk for allergic reaction

Implementation: Administer as prescribed; monitor liver function; assess for adverse effects.

Evaluation: Evaluate patient tolerance, absence of adverse reactions, and successful resolution of infection.

Patient/Family Teaching

  • Take medication exactly as prescribed.
  • Report any signs of hepatic problems (jaundice, dark urine) or allergic reactions.
  • Use in conjunction with other measures for infection control.

Special Considerations

Black Box Warnings:

  • None currently issued.

Genetic Factors: No known pharmacogenomic considerations.

Lab Test Interference: May elevate liver function tests; interpret results accordingly.

Overdose Management

Signs/Symptoms: Nausea, vomiting, abdominal pain, possible hepatic dysfunction.

Treatment: Supportive care; no specific antidote; monitor liver function; consider activated charcoal if ingestion is recent.

Storage and Handling

Storage: Store at room temperature, 20-25°C (68-77°F).

Stability: Stable under recommended storage conditions.

🛡️ 5 Critical Medication Safety Tips for Nurses

1

Triple-Check High-Risk Medications

Always have another nurse verify insulin, heparin, warfarin, and chemotherapy drugs. These "high-alert" medications cause the most serious errors. Check concentration, dose calculation, and pump settings twice.

2

Know Look-Alike, Sound-Alike Drugs

Common mix-ups: hydromorphone/morphine, Celebrex/Celexa, Zyprexa/Zyrtec. Always use BOTH generic and brand names, read labels twice, and use barcode scanning when available. One wrong letter can be fatal.

3

Assess Before AND After Giving Meds

Check vitals before cardiac meds, pain levels before analgesics, and blood glucose before insulin. Always reassess within 30 minutes to evaluate effectiveness and watch for adverse reactions.

4

Watch for Drug Interactions

Common dangerous combinations: warfarin + aspirin (bleeding), ACE inhibitors + potassium (hyperkalemia), digoxin + diuretics (toxicity). Always check drug interactions before administering new medications.

5

Educate Your Patients

Teach patients medication names, purposes, major side effects, and what to report. Informed patients catch errors and improve compliance. Always encourage questions - an educated patient is a safer patient.

⚡ Remember: When in doubt, don't give it out! It's always safer to double-check than regret later.

⚠️ Medical Disclaimer

This drug guide is for educational purposes only and is NOT intended for clinical use. Always consult current prescribing information, healthcare providers, and institutional protocols before administering any medication. Do not use this information for patient care decisions.