Generic Name

Insulin Aspart Protamine Recombinant & Insulin Aspart Recombinant

---

Classification

FDA Approved Indications

• Management of blood glucose levels in patients with diabetes mellitus type 1 and type 2

Mechanism of Action

Insulin Aspart is a rapid-acting insulin analog that facilitates cellular glucose uptake, inhibits hepatic glucose production, and promotes storage of glucose as glycogen. The protamine component prolongs the action of insulin Aspart, creating an intermediate-duration insulin.

Dosage and Administration

Adult: Dosing individualized based on patient needs; typical starting dose varies

Pediatric: Dosing individualized; initiated based on blood glucose monitoring

Geriatric: Careful dosing adjustments recommended, considering renal and hepatic function

Renal Impairment: Use with caution; may require dose adjustments

Hepatic Impairment: Use with caution; monitor closely and adjust doses accordingly

Pharmacokinetics

Absorption: Rapid after subcutaneous injection

Distribution: Widely distributed throughout body water compartments

Metabolism: Metabolized primarily in the liver and kidneys

Excretion: Metabolites excreted via renal pathways

Half Life: Approximately 1 hour for insulin Aspart; duration influenced by formulation and site of injection

Contraindications

• Hypersensitivity to insulin Aspart or any excipients

Precautions

• Risk of hypoglycemia, especially in those with renal or hepatic impairment, during concurrent illness, or when changing insulin types

Adverse Reactions - Common

• Hypoglycemia (Common)
• Injection site reactions (Less common)

Adverse Reactions - Serious

• Severe hypoglycemia (Rare)
• Allergic reactions including anaphylaxis (Rare)

Drug-Drug Interactions

• Use with other hypoglycemic agents (e.g., sulfonylureas) may increase hypoglycemia risk

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Patient/Family Teaching

• Instruct on proper injection technique, site rotation, and storage
• Recognize signs of hypoglycemia and hyperglycemia and how to respond
• Importance of regular blood glucose monitoring

Special Considerations

Black Box Warnings:

• Potential for severe hypoglycemia

Genetic Factors: None specific

Lab Test Interference: May alter some laboratory glucose tests

Overdose Management

Signs/Symptoms: Severe hypoglycemia: sweating, trembling, confusion, seizures, unconsciousness

Treatment: Administer oral glucose if alert; in severe cases, provide IV glucose or glucagon, and seek emergency care

Storage and Handling

Storage: Store unopened vials/cartridges in the refrigerator; opened vials may be kept at room temperature for up to 28 days

Stability: Stable at room temperature up to 28 days once opened