Generic Name

Naftifine Hydrochloride

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Classification

FDA Approved Indications

• Treatment of topical fungal infections such as tinea corporis, tinea cruris, tinea pedis, and cutaneous candidiasis

Mechanism of Action

Naftifine inhibits squalene epoxidase, an enzyme involved in ergosterol synthesis, leading to disruption of fungal cell membrane synthesis and integrity.

Dosage and Administration

Adult: Apply a thin layer to affected area once or twice daily for the prescribed duration.

Pediatric: Data limited; use as directed by a healthcare provider, typically similar to adult dosing.

Geriatric: No specific dosage adjustments provided; monitor for tolerability.

Renal Impairment: Use with caution; no specific adjustments established.

Hepatic Impairment: Use with caution; no specific adjustments established.

Pharmacokinetics

Absorption: Minimal systemic absorption when used topically.

Distribution: Distributed locally in skin tissues.

Metabolism: Primarily topical; systemic metabolism is minimal.

Excretion: Excreted mainly in skin desquamation; systemic excretion unknown.

Half Life: Not applicable; systemic absorption is minimal.

Contraindications

• Hypersensitivity to naftifine or other allylamines.

Precautions

• Avoid contact with eyes, mucous membranes, or open wounds.
• Use with caution in patients with known sensitivity to topical antifungals.

Adverse Reactions - Common

• Application site redness or irritation (Common)
• Burning sensation at application site (Common)

Adverse Reactions - Serious

• Allergic contact dermatitis (Rare)
• Severe skin reactions (Rare)

Drug-Drug Interactions

• None well documented; consult current sources.

Drug-Food Interactions

• None specific.

Drug-Herb Interactions

• Limited data; avoid concomitant use with other topical agents unless directed.

Nursing Implications

Patient/Family Teaching

• Apply medication as directed, typically once or twice daily.
• Keep the area clean and dry.
• Report any signs of allergic reaction or worsening infection.
• Avoid contact with eyes, mucous membranes, and broken skin.

Special Considerations

Black Box Warnings:

• None

Genetic Factors: Not applicable.

Lab Test Interference: No known interference.

Overdose Management

Signs/Symptoms: Local skin irritation or allergic reactions.

Treatment: Remove applied medication, provide symptomatic relief, and seek medical attention if necessary.

Storage and Handling

Storage: Store at room temperature, away from heat and moisture.

Stability: Stable under recommended conditions; follow manufacturer guidelines.