Generic Name

Natamycin

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Classification

FDA Approved Indications

• Ocular fungal infections, such as fungal keratitis

Mechanism of Action

Natamycin binds to ergosterol in fungal cell membranes, disrupting membrane integrity and causing cell death.

Dosage and Administration

Adult: Apply as a 5% ophthalmic suspension to affected eye(s) as directed by the physician, typically every 1-2 hours initially.

Pediatric: Use as prescribed by a healthcare provider; dosing may be similar to adults, but specific guidelines should be followed.

Geriatric: No specific adjustments required, but caution in elderly with other ocular conditions.

Renal Impairment: No specific dosage adjustment; systemic absorption is minimal.

Hepatic Impairment: No specific dosage adjustment; primarily used topically. Systemic effects are rare.

Pharmacokinetics

Absorption: Minimal systemic absorption when used topically.

Distribution: Primarily localized to ocular tissues.

Metabolism: Not extensively metabolized; primarily remains unmetabolized topical form.

Excretion: Minor systemic absorption; excreted via tear drainage and local ocular tissues.

Half Life: Not well-defined; topical application with local action.

Contraindications

• Hypersensitivity to natamycin or other components of the formulation.

Precautions

• Monitor for allergic reactions; use with caution in patients with known hypersensitivity to polyene antifungals.

Adverse Reactions - Common

• Transient stinging or burning upon application. (Common)
• Eyedrops irritation or redness. (Uncommon)

Adverse Reactions - Serious

• Allergic reactions, including swelling or rash. (Rare)
• Corneal edema or epithelial defect. (Rare)

Drug-Drug Interactions

N/A

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Patient/Family Teaching

• Apply medication exactly as prescribed.
• Avoid touching the tip of the dropper to any surface.
• Report any worsening symptoms, side effects, or signs of allergic reaction.
• Use medication for the full prescribed duration, even if symptoms improve.

Special Considerations

Black Box Warnings:

• None currently issued.

Genetic Factors: None relevant.

Lab Test Interference: Not known to interfere with laboratory tests.

Overdose Management

Signs/Symptoms: Rare, but excessive application may cause increased irritation or adverse effects.

Treatment: Supportive care; discontinue medication and provide symptomatic relief.

Storage and Handling

Storage: Store at room temperature, protected from light.

Stability: Stable until the expiration date on the packaging.