Nurses Compass
Drug Guide
Tavaborole
Classification
Therapeutic: Antifungal
Pharmacological: Topical Oxaborole antifungal agent
FDA Approved Indications
- Onychomycosis (fungal infections of the toenails or fingernails) caused by dermatophytes
Mechanism of Action
Tavaborole inhibits fungal leucyl-tRNA synthetase, disrupting fungal protein synthesis, leading to fungal cell death.
Dosage and Administration
Adult: Apply a thin layer to affected nails once daily for 48 weeks.
Pediatric: Safety and efficacy in children have not been established.
Geriatric: No specific dosage adjustments, but monitor closely for adverse effects.
Renal Impairment: No dosage adjustment necessary.
Hepatic Impairment: No dosage adjustment necessary.
Pharmacokinetics
Absorption: Minimal systemic absorption when applied topically.
Distribution: Primarily localized in the nail tissue.
Metabolism: Metabolized locally in the nail keratin.
Excretion: Excreted in nail tissue; systemic excretion not significant.
Half Life: N/A (local topical use).
Contraindications
- Hypersensitivity to tavaborole or any component of the formulation.
Precautions
- Avoid contact with eyes or mucous membranes.
- Use with caution in patients with nail trauma or conditions that may facilitate systemic absorption.
Adverse Reactions - Common
- Application site erythema (Common)
- Itching (Common)
- LBU (onychomycosis) persistence or worsening without improvement (Common)
Adverse Reactions - Serious
- Allergic contact dermatitis (Uncommon)
- Unusual systemic adverse effects: very rare. (Rare)
Drug-Drug Interactions
N/ADrug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Assess nail condition and response to therapy periodically.
Diagnoses:
- Impaired skin integrity related to topical application.
- Knowledge deficit regarding treatment application.
Implementation: Instruct patient on proper nail cleaning and application technique.
Evaluation: Monitor for signs of improvement or adverse reactions.
Patient/Family Teaching
- Apply medication as directed, focusing on affected nails.
- Keep nails dry and clean.
- Notify healthcare provider if irritation, allergic reactions, or worsening occurs.
- Complete the full course of therapy, even if symptoms improve.
Special Considerations
Black Box Warnings: N/A
Genetic Factors: None identified.
Lab Test Interference: Minimal systemic absorption; unlikely to affect lab tests.
Overdose Management
Signs/Symptoms: Local irritation or allergic reactions.
Treatment: Discontinue use and provide supportive care; no specific antidote.
Storage and Handling
Storage: Store at room temperature, away from moisture and heat.
Stability: Stable when stored properly.