Drug Guide
Alclometasone Dipropionate
Classification
Therapeutic: Topical corticosteroid
Pharmacological: Glucocorticoid
FDA Approved Indications
- Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Mechanism of Action
Alclometasone Dipropionate is a potent anti-inflammatory agent that suppresses inflammatory, immune, and fibroblastic activity through vasoconstriction and inhibition of multiple inflammatory cytokines.
Dosage and Administration
Adult: Apply a thin layer to affected area 2-4 times daily.
Pediatric: Same as adult, but use with caution in children due to increased absorption and potential for systemic effects.
Geriatric: Use with caution; monitor for skin atrophy and other local side effects.
Renal Impairment: Data not available; systemic absorption is minimal.
Hepatic Impairment: Data not available.
Pharmacokinetics
Absorption: Minimal when used topically under occlusion; higher absorption may occur with broken skin or occlusion.
Distribution: Primarily localized in skin tissues.
Metabolism: Metabolized in skin tissues; systemic metabolism data limited due to minimal absorption.
Excretion: Excreted via feces and urine after systemic absorption, which is minimal.
Half Life: Not well characterized for topical use; systemic half-life is short of plasma corticosteroids.
Contraindications
- Hypersensitivity to alclometasone or any component of the formulation.
Precautions
- Use with caution in on areas of skin infection, or in compromised skin barriers; avoid long-term use on large areas, especially in children; use with caution in patients with conditions like psoriasis or rosacea.
Adverse Reactions - Common
- Skin burning, itching, irritation (Uncommon)
- Atrophic striae, skin thinning (Less common)
Adverse Reactions - Serious
- Adrenal suppression (rare) (Rare)
- Secondary infections, including fungal or bacterial superinfection (Rare)
Drug-Drug Interactions
- Potent CYP3A4 inhibitors may increase corticosteroid levels.
Drug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Assess skin condition before and during therapy; monitor for signs of skin atrophy.
Diagnoses:
- Impaired skin integrity related to corticosteroid therapy.
Implementation: Apply as directed, avoiding contact with face, groin, or underarms unless directed; do not cover with occlusive dressings unless instructed.
Evaluation: Monitor for improvement of skin condition and adverse effects.
Patient/Family Teaching
- Use medication exactly as prescribed.
- Apply thin layer, avoiding eyes and face.
- Report any signs of skin deterioration, new infections, or adverse reactions.
- Avoid occlusive dressings unless advised.
Special Considerations
Black Box Warnings:
- Prolonged use may cause skin atrophy, systemic absorption, and HPA axis suppression, especially in children.
Genetic Factors: Not specified.
Lab Test Interference: Minimal with topical use; systemic effects are rare.
Overdose Management
Signs/Symptoms: Signs of systemic corticosteroid excess, such as hyperglycemia, weight gain, or adrenal suppression (rare).
Treatment: Discontinue use; supportive measures; consult toxicology if significant systemic absorption suspected.
Storage and Handling
Storage: Store at room temperature, away from light and moisture.
Stability: Stable under normal conditions.