Home Drug Guide Bacitracin Zinc

Drug Guide

Generic Name

Bacitracin Zinc

Brand Names Ziba-rx

Classification

Therapeutic: Antibiotic, Topical

Pharmacological: Polypeptide Antibiotic

FDA Approved Indications

Treatment of skin infections caused by susceptible bacteria

Mechanism of Action

Bacitracin inhibits bacterial cell wall synthesis by interfering with peptidoglycan precursors, leading to cell lysis.

Dosage and Administration

Adult: Apply a thin layer to the affected area 1-3 times daily or as directed by a physician.

Pediatric: Use as directed; typically similar to adult dosing, but caution advised in infants and young children.

Geriatric: Adjust based on site and severity of infection, with attention to skin integrity.

Renal Impairment: Not typically used systemically; mainly topical, so renal adjustments are usually unnecessary.

Hepatic Impairment: Not applicable; topical use. Surveillance in case of systemic absorption.

Pharmacokinetics

Absorption: Minimal systemic absorption when applied topically.

Distribution: Primarily remains localized in skin.

Metabolism: Not metabolized systemically; remains localized.

Excretion: Excreted in the skin, with minimal systemic absorption.

Half Life: Not applicable; topical application.

Contraindications

Hypersensitivity to bacitracin or other components.
History of allergic contact dermatitis with bacitracin.

Precautions

Use with caution in patients with a known hypersensitivity to other antibiotics; avoid excessive or prolonged use to prevent sensitization.

Adverse Reactions - Common

Local skin irritation or contact dermatitis (Rare)
Allergic contact dermatitis (Rare)

Adverse Reactions - Serious

Anaphylaxis (Very rare)

Drug-Drug Interactions

N/A

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Inspect affected area for signs of infection and allergic reactions.

Diagnoses:

Risk for contact dermatitis
Impaired skin integrity

Implementation: Apply as directed, ensuring proper skin cleansing before application.

Evaluation: Monitor for resolution of infection and for adverse skin reactions.

Patient/Family Teaching

Use as directed and complete the full course.
Report any signs of allergic reaction or irritation.
Keep the medication out of reach of children.

Special Considerations

Black Box Warnings:

None at present.

Genetic Factors: No known genetic considerations.

Lab Test Interference: No significant interference expected with laboratory tests.

Overdose Management

Signs/Symptoms: Excessive application leading to systemic absorption may cause nephrotoxicity or allergic reactions.

Treatment: Discontinue use; provide supportive care as needed, including hydration if nephrotoxicity occurs.

Storage and Handling

Storage: Store at room temperature, 20°C to 25°C (68°F to 77°F).

Stability: Stable under recommended storage conditions; keep container closed.