Home Drug Guide Betamethasone Valerate

Drug Guide

Generic Name

Betamethasone Valerate

Brand Names Valisone, Beta-val, Betaderm, Betatrex, Luxiq, Valnac, Dermabet

Classification

Therapeutic: Anti-inflammatory, Corticosteroid

Pharmacological: Glucocorticoid

FDA Approved Indications

Inflammatory dermatoses (e.g., eczema, psoriasis)
Atopic dermatitis
Allergic contact dermatitis

Mechanism of Action

Betamethasone Valerate suppresses inflammation and immune responses by inhibiting multiple inflammatory cytokines, phospholipase A2, and reducing the synthesis of inflammatory mediators.

Dosage and Administration

Adult: Apply thin layer to affected area 1-2 times daily as directed by physician.

Pediatric: Use as directed by physician; generally, lower potency and careful monitoring recommended.

Geriatric: Adjust dose based on severity and response; monitor for signs of adrenal suppression.

Renal Impairment: Use with caution; no specific dosage adjustment established.

Hepatic Impairment: Use with caution; monitor for systemic effects.

Pharmacokinetics

Absorption: Minimal systemic absorption when used topically; systemic absorption can increase with larger or occluded areas.

Distribution: Systemically available fraction binds to corticosteroid-binding globulin and albumin.

Metabolism: Metabolized primarily in the liver via hepatic enzymes.

Excretion: Excreted mainly in urine as metabolites.

Half Life: Approximately 2-4 hours for systemic circulation.

Contraindications

Hypersensitivity to Betamethasone Valerate or other corticosteroids.
Viral skin infections (e.g., herpes simplex, varicella).
Fungal skin infections.

Precautions

Avoid use over large skin areas or occlusive dressings.
Use cautiously in children, infants, and the elderly.
Long-term use may cause skin thinning, systemic absorption, and adrenal suppression.
Pregnancy/lactation: Use only if benefits outweigh risks; consult healthcare provider.

Adverse Reactions - Common

Skin irritation (Common)
Dryness or burning at application site (Common)

Adverse Reactions - Serious

Adrenal suppression (Rare)
Skin atrophy (Rare)
Hypo-pigmentation (Rare)
Secondary infection (Rare)

Drug-Drug Interactions

Other systemic corticosteroids, immunosuppressants, live vaccines.

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Monitor skin condition and response. Watch for signs of systemic corticosteroid effects.

Diagnoses:

Risk of skin atrophy
Impaired skin integrity

Implementation: Apply as prescribed; avoid occlusive dressings unless directed.

Evaluation: Assess for reduction in inflammation and adverse effects.

Patient/Family Teaching

Use exactly as prescribed, do not cover with bandages unless directed.
Report signs of skin changes, infections, or systemic side effects.
Avoid contact with eyes and mucous membranes.

Special Considerations

Black Box Warnings:

Potential for systemic absorption leading to systemic corticosteroid effects, especially with occlusive use or over large areas.

Genetic Factors: No specific genetic concerns documented.

Lab Test Interference: May suppress adrenal function tests if used extensively.

Overdose Management

Signs/Symptoms: Features of systemic corticosteroid overexposure: weight gain, osteoporosis, adrenal suppression.

Treatment: Discontinue medication gradually; provide supportive care and monitor response.

Storage and Handling

Storage: Store at room temperature, 15-30°C, away from moisture and light.

Stability: Stable under recommended storage conditions for shelf life.