Home Drug Guide Butenafine Hydrochloride

Drug Guide

Generic Name

Butenafine Hydrochloride

Brand Names Mentax, Lotrimin Ultra, Mentax-tc

Classification

Therapeutic: Antifungal

Pharmacological: Allylamine antifungal

FDA Approved Indications

Treatment of dermatophyte infections of the skin (tinea corporis, tinea cruris, tinea pedis)

Mechanism of Action

Butenafine inhibits squalene epoxidase, an enzyme involved in ergosterol synthesis in fungi, leading to accumulation of squalene and disruption of fungal cell membrane synthesis.

Dosage and Administration

Adult: Apply a thin layer to affected area once daily for 2-4 weeks.

Pediatric: Dosage based on weight and clinical judgment; follow adult regimen unless directed otherwise.

Geriatric: Use with caution; monitor for efficacy and adverse effects.

Renal Impairment: No specific adjustment necessary.

Hepatic Impairment: No specific adjustment necessary.

Pharmacokinetics

Absorption: Minimal systemic absorption when applied topically.

Distribution: Primarily localized in skin tissues.

Metabolism: Metabolized in the skin; systemic metabolism not well-documented.

Excretion: Excretion pathways not well-documented due to topical use.

Half Life: N/A for topical application.

Contraindications

Hypersensitivity to butenafine or any component of the formulation.

Precautions

Use with caution in individuals with scalp or hair-bearing areas due to potential for increased absorption.

Adverse Reactions - Common

Local skin irritation (Uncommon)
Itching, burning sensation (Uncommon)

Adverse Reactions - Serious

Allergic contact dermatitis (Rare)
Excessive skin irritation or allergic reaction (Rare)

Drug-Drug Interactions

N/A

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Inspect affected areas for extent and severity of infection.

Diagnoses:

Risk for skin integrity impairment related to fungal infection.

Implementation: Instruct patient on proper topical application, hand hygiene, and duration of therapy.

Evaluation: Monitor for resolution of symptoms and signs of infection.

Patient/Family Teaching

Apply medication exactly as prescribed.
Avoid contact with eyes, mouth, or mucous membranes.
Complete full course of therapy even if symptoms improve.
Report any signs of allergic reaction or skin irritation.

Special Considerations

Black Box Warnings: N/A

Genetic Factors: N/A

Lab Test Interference: None reported.

Overdose Management

Signs/Symptoms: Local skin irritation or allergic reaction if overdose occurs.

Treatment: Discontinue use and manage symptoms supportively.

Storage and Handling

Storage: Store at room temperature, away from moisture and heat.

Stability: Stable for the duration of labeled expiry date.