Drug Guide
Calcium Carbonate
Classification
Therapeutic: Antacid, Mineral supplement
Pharmacological: Calcium salt, Histamine H2 receptor antagonist
FDA Approved Indications
- Heartburn and acid indigestion relief
- Prevention of stress ulcers in hospitalized patients
- Calcium supplementation in deficiency
Mechanism of Action
Calcium carbonate neutralizes stomach acid through chemical reaction, providing symptomatic relief of indigestion and acting as a calcium supplement.
Dosage and Administration
Adult: Typically 500-1000 mg every 4-6 hours as needed, not to exceed 7500 mg per day.
Pediatric: Dosing varies; consult specific pediatric guidelines.
Geriatric: Adjustments based on kidney function; monitor for calcium overload.
Renal Impairment: Use cautiously; risk of hypercalcemia.
Hepatic Impairment: No specific adjustment necessary.
Pharmacokinetics
Absorption: Absorbed from the gastrointestinal tract, but absorption is limited and depends on the dose.
Distribution: Widely distributed; calcium binds to plasma proteins.
Metabolism: Not significantly metabolized.
Excretion: Excreted primarily via the kidneys.
Half Life: Approximately 1-3 hours; varies with serum calcium levels.
Contraindications
- Hypocalcemia
- Kidney stones caused by hypercalcemia
Precautions
- Use with caution in patients with renal impairment, hypercalcemia, or on medications affecting calcium metabolism.
Adverse Reactions - Common
- Constipation (Common)
- Stomach upset (Common)
Adverse Reactions - Serious
- Hypercalcemia (Rare)
- Kidney stones (Rare)
Drug-Drug Interactions
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Drug-Food Interactions
- Avoid taking with high-iron foods or supplements simultaneously, as iron absorption may be decreased.
Drug-Herb Interactions
N/ANursing Implications
Assessment: Monitor serum calcium and renal function in long-term use.
Diagnoses:
- Risk for electrolyte imbalance
- Impaired gastrointestinal comfort
Implementation: Administer after meals for best effect; chew thoroughly if chewable.
Evaluation: Assess relief of symptoms and monitor calcium levels.
Patient/Family Teaching
- Take as directed and do not exceed recommended dose.
- Notify healthcare provider if symptoms persist.
- Report signs of hypercalcemia (nausea, vomiting, confusion).
Special Considerations
Black Box Warnings: N/A
Genetic Factors: None specified.
Lab Test Interference: May interfere with serum calcium, phosphate, and magnesium tests.
Overdose Management
Signs/Symptoms: Nausea, vomiting, confusion, muscle weakness, or irregular heartbeat.
Treatment: Supportive care; calcium chelation or dialysis if severe hypercalcemia occurs.
Storage and Handling
Storage: Store at room temperature, away from moisture and light.
Stability: Stable under normal conditions.