Generic Name

Sucralfate

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Classification

FDA Approved Indications

• Treatment of active duodenal ulcer
• Maintenance of healing of duodenal ulcers

Mechanism of Action

Sucralfate forms a protective barrier over ulcers and erosions, adhering to the base of the ulcer and protecting the area from further injury by acid, enzymes, and bile salts, thereby facilitating healing.

Dosage and Administration

Adult: Typically 1 gram orally 4 times a day before meals and at bedtime.

Pediatric: Not generally used in children; consult specific pediatric dosing guidelines.

Geriatric: Similar dosing to adults; monitor renal function.

Renal Impairment: Adjust dosages as needed; use with caution in renal impairment.

Hepatic Impairment: No specific adjustments; monitor as clinically indicated.

Pharmacokinetics

Absorption: Minimal systemic absorption; primarily local action in the GI tract.

Distribution: Not well characterized due to minimal absorption.

Metabolism: Not extensively metabolized; functions locally.

Excretion: Excreted primarily in feces; negligible systemic absorption minimizes renal excretion considerations.

Half Life: N/A—acts locally in the GI tract.

Contraindications

• Hypersensitivity to sucralfate or any component.

Precautions

• Use cautiously in patients with kidney impairment due to aluminum content; may interfere with absorption of other medications.

Adverse Reactions - Common

• Constipation (Common)
• Dizziness (Less common)

Adverse Reactions - Serious

• Aluminum accumulation leading to toxicity in renal failure (Rare)
• Hypersensitivity reactions including rash or urticaria (Rare)

Drug-Drug Interactions

• Potential to interfere with absorption of many oral drugs — administer other drugs at least 2 hours before or after sucralfate.

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Patient/Family Teaching

• Take on an empty stomach, 1 hour before meals and at bedtime.
• Do not take other medications within 2 hours of sucralfate.
• Report signs of constipation or allergic reactions.

Special Considerations

Black Box Warnings: N/A

Genetic Factors: N/A

Lab Test Interference: May interfere with certain lab tests for blood glucose or other parameters; inform laboratory personnel of sucralfate use.

Overdose Management

Signs/Symptoms: N/A — overdose unlikely due to minimal absorption.

Treatment: Supportive care if gastrointestinal symptoms occur; no specific antidote.

Storage and Handling

Storage: Store at room temperature, 15-30°C (59-86°F).

Stability: Stable under proper storage conditions.