Home Drug Guide Ioversol

Drug Guide

Generic Name

Ioversol

Brand Names Optiray 160, Optiray 240, Optiray 300, Optiray 320, Optiray 350

Classification

Therapeutic: Contrast Agent, Diagnostic

Pharmacological: Nonionic, iodinated radiopaque contrast agent

FDA Approved Indications

X-ray imaging of vascular system and body cavities where contrast enhancement is needed

Mechanism of Action

Ioversol is an iodinated contrast agent that increases the attenuation of X-rays in blood vessels and tissues, enhancing contrast in radiographic images.

Dosage and Administration

Adult: Dosage varies based on procedure; generally 50-150 mL administered via IV, with volume adjusted based on body habitus and imaging requirements.

Pediatric: Dosing is weight-based; consult specific protocols. Usually 1-2 mL/kg as a single dose.

Geriatric: Adjusted based on renal function; use caution in elderly patients due to risk of renal impairment.

Renal Impairment: Reduce dose and ensure adequate hydration; avoid in severe renal impairment if possible.

Hepatic Impairment: No specific adjustments, but caution advised.

Pharmacokinetics

Absorption: Not absorbed orally; administered intravenously.

Distribution: Rapidly distributes in extracellular fluid.

Metabolism: Excreted largely unchanged in urine.

Excretion: Primarily renal excretion.

Half Life: Approximately 2 hours in patients with normal renal function.

Contraindications

Known allergy to iodine or iodinated contrast media
History of severe hypersensitivity reactions to contrast agents

Precautions

Patients with renal impairment, asthma, or allergies to other contrast media should be carefully evaluated before administration.
Pre-medication may be considered in at-risk patients.

Adverse Reactions - Common

Nausea (Frequently)
Warm feeling or flushing (Common)
Pruritus or rash (Uncommon)

Adverse Reactions - Serious

Anaphylactic reactions (Rare)
Contrast-induced nephropathy (CIN) (Rare but serious)

Drug-Drug Interactions

Other nephrotoxic drugs (e.g., aminoglycosides, NSAIDs) increase risk of renal impairment

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Assess for allergy history, renal function, and hydration status before administration.

Diagnoses:

Risk for allergic reaction
Risk for renal impairment

Implementation: Ensure proper hydration, monitor vital signs, and observe for allergic or adverse reactions during and after administration.

Evaluation: Monitor renal function post-procedure, reassess for allergic symptoms.

Patient/Family Teaching

Inform about possible sensations during injection (warmth, flushing).
Advise to report any allergic symptoms immediately.
Emphasize importance of hydration to reduce renal risk.

Special Considerations

Black Box Warnings:

Risk of anaphylaxis and hypersensitivity reactions.
Potential for contrast-induced nephropathy (CIN).

Genetic Factors: No specific genetic concerns identified.

Lab Test Interference: May interfere with thyroid function tests due to iodine content.

Overdose Management

Signs/Symptoms: Signs of hypersensitivity, renal impairment, or adverse reactions.

Treatment: Supportive care, treat allergic reactions with antihistamines or epinephrine, ensure adequate hydration, and renal support if necessary.

Storage and Handling

Storage: Store at controlled room temperature, 20°C to 25°C (68°F to 77°F).

Stability: Stable until expiration date when stored properly.