Drug Guide
Sincalide
Classification
Therapeutic: Digestive agent
Pharmacological: Cholecystokinetic agent
FDA Approved Indications
- Cholecystokinetic test to stimulate gallbladder contraction during diagnostic evaluation
Mechanism of Action
Sincalide is a synthetic peptide that mimics naturally occurring cholecystokinin (CCK). It stimulates the release of digestive enzymes from the pancreas and causes contraction of the gallbladder, aiding in its assessment.
Dosage and Administration
Adult: Typically, 0.02 mcg/kg given intravenously over 30 seconds. The dosage may vary based on clinical setting.
Pediatric: Use based on clinical judgment; consult specific guidelines or manufacturer instructions.
Geriatric: No specific dosage adjustments; monitor for increased sensitivity.
Renal Impairment: Use with caution; no specific adjustments established.
Hepatic Impairment: Use with caution; no specific adjustments established.
Pharmacokinetics
Absorption: Rapid intravenous absorption.
Distribution: Widely distributed with rapid clearance.
Metabolism: Metabolized primarily in the liver.
Excretion: Excreted mainly in the urine.
Half Life: Approximately 10-15 minutes.
Contraindications
- Hypersensitivity to sinc između
- Gallbladder obstruction
Precautions
- Use cautiously in patients with suspected or known gallbladder disease, pancreatitis, or bowel obstruction.
Adverse Reactions - Common
- Nausea (Common)
- Abdominal cramps (Common)
Adverse Reactions - Serious
- Allergic reactions including rash, itching, anaphylaxis (Rare)
- Severe abdominal pain, signs of pancreatitis (Rare)
Drug-Drug Interactions
- None well-documented; caution with other drugs affecting gastrointestinal motility.
Drug-Food Interactions
- None established.
Drug-Herb Interactions
- None established.
Nursing Implications
Assessment: Monitor for allergic reactions and adverse effects. Assess gallbladder function as indicated.
Diagnoses:
- Risk of allergic reaction
Implementation: Administer as prescribed, observe patient response, and be prepared for emergency management of allergic reactions.
Evaluation: Effectiveness of gallbladder stimulation and absence of adverse reactions.
Patient/Family Teaching
- Report any allergic reactions immediately.
- Understand this medication is used during diagnostic tests.
- Follow any specific instructions provided by healthcare provider.
Special Considerations
Black Box Warnings:
- None at this time.
Genetic Factors: None established.
Lab Test Interference: May alter gallbladder imaging results during cholangiography.
Overdose Management
Signs/Symptoms: Severe abdominal pain, allergic reactions, signs of pancreatitis.
Treatment: Supportive care; discontinue drug; symptomatic management; emergency interventions as needed.
Storage and Handling
Storage: Store at controlled room temperature, away from light and moisture.
Stability: Stable according to manufacturer guidelines; check expiration date.