Home Drug Guide Meprednisone

Drug Guide

Generic Name

Meprednisone

Brand Names Betapar

Classification

Therapeutic: Anti-inflammatory corticosteroid

Pharmacological: Glucocorticoid

FDA Approved Indications

Inflammatory and allergic conditions

Mechanism of Action

Meprednisone works by binding to glucocorticoid receptors, modulating gene expression to suppress inflammation, immune responses, and allergic reactions.

Dosage and Administration

Adult: Dose varies based on condition; typically 4-16 mg daily, divided doses.

Pediatric: Dose based on weight/age; consulting a pediatrician is recommended.

Geriatric: Start at lower end of dosing to minimize side effects; close monitoring advised.

Renal Impairment: Adjust dose as needed; monitor renal function.

Hepatic Impairment: Use with caution; hepatic function may influence metabolism.

Pharmacokinetics

Absorption: Well-absorbed orally.

Distribution: Widely distributed throughout body tissues.

Metabolism: Primarily hepatic metabolism.

Excretion: Renally excreted metabolites.

Half Life: Approximately 2-3 hours.

Contraindications

Systemic fungal infections

Precautions

Use with caution in infections, diabetes, osteoporosis, and ophthalmic herpes simplex. Monitor blood glucose and bone density with long-term therapy.

Adverse Reactions - Common

Increased appetite (Common)
Mood changes (Common)
Fluid retention (Common)

Adverse Reactions - Serious

Adrenal suppression (Serious)
Osteoporosis (Serious)
Infections (due to immunosuppression) (Serious)

Drug-Drug Interactions

NSAIDs (increased gastric risk),Anticoagulants (altered effects),Vaccines (reduced efficacy)

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Monitor blood pressure, blood glucose, signs of infection, and electrolyte balance.

Diagnoses:

Risk for infection
Impaired skin integrity

Implementation: Administer with food to decrease GI upset, monitor patient response and side effects.

Evaluation: Assess for reduced inflammation and monitor side effects.

Patient/Family Teaching

Take medication exactly as prescribed.
Report signs of infection, mood changes, or osteoporosis.
Avoid live vaccines during therapy.

Special Considerations

Black Box Warnings:

Long-term use can cause adrenal suppression, osteoporosis, and increased susceptibility to infections.

Genetic Factors: Genetic variations may influence metabolism.

Lab Test Interference: May alter serum glucose, electrolyte levels, and immune response tests.

Overdose Management

Signs/Symptoms: Symptoms of overdose may include Cushingoid features, increased blood sugar, and electrolyte imbalance.

Treatment: Supportive care; dose reduction or discontinuation.

Storage and Handling

Storage: Store at room temperature away from moisture and heat.

Stability: Stable within labeled expiration date.