Drug Guide
Perfluorohexyloctane
Classification
Therapeutic: Ophthalmic lubricant
Pharmacological: Perfluorocarbon liquid
FDA Approved Indications
- Treatment of dry eye disease, especially evaporative dry eye due to meibomian gland dysfunction
Mechanism of Action
Forms a temporary, lubricating barrier on the surface of the eye to reduce tear evaporation and improve ocular surface hydration.
Dosage and Administration
Adult: Instill 1-2 drops into the affected eye(s) once or twice daily, as needed.
Pediatric: Data limited; use only if prescribed by ophthalmologist.
Geriatric: Adjust dosage based on patient's clinical response and tolerability.
Renal Impairment: No specific adjustments needed; consider ocular route.
Hepatic Impairment: Data limited; use with caution.
Pharmacokinetics
Absorption: Minimal systemic absorption due to topical ocular application.
Distribution: Localized on ocular surface.
Metabolism: Not metabolized systemically.
Excretion: Excreted via tear film; minimal systemic excretion.
Half Life: N/A; localized effect duration varies, but typically few hours.
Contraindications
- Known hypersensitivity to perfluorocarbons or any component of the formulation.
Precautions
- Use with caution in patients with ocular infections or injuries.
- Monitor for adverse reactions such as visual disturbances or irritation.
Adverse Reactions - Common
- Transient blurred vision (Common)
- Ocular irritation or redness (Common)
Adverse Reactions - Serious
- Severe allergic reaction, including swelling or difficulty breathing (Rare)
- Significant ocular pain or signs of infection (Rare)
Drug-Drug Interactions
- Limited data; generally minimal due to topical application.
Drug-Food Interactions
- No known interactions.
Drug-Herb Interactions
- None established.
Nursing Implications
Assessment: Assess ocular surface condition, visual acuity, and patient’s response.
Diagnoses:
- Risk for impaired vision
- Ineffective peripheral tissue perfusion related to ocular surface irritation.
Implementation: Administer as prescribed, ensuring proper instillation technique.
Evaluation: Monitor symptom relief, adverse reactions, and ocular health status.
Patient/Family Teaching
- Instruct to use the drops as directed.
- Warn about possible visual disturbances following instillation.
- Advise to seek medical attention if adverse reactions occur or symptoms worsen.
Special Considerations
Black Box Warnings:
- None
Genetic Factors: None known.
Lab Test Interference: None.
Overdose Management
Signs/Symptoms: No systemic overdose expected; ocular overdose may cause increased irritation or blurred vision.
Treatment: Rinse eye with sterile saline or water; provide symptomatic care; seek ophthalmic evaluation if necessary.
Storage and Handling
Storage: Store at room temperature, away from direct sunlight and moisture.
Stability: Stable until the expiration date on the package.