Generic Name

Pemirolast Potassium

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Classification

FDA Approved Indications

• Allergic conjunctivitis

Mechanism of Action

Pemirolast stabilizes mast cell membranes, preventing the release of inflammatory mediators like histamine, thereby reducing allergic responses.

Dosage and Administration

Adult: One drop in each affected eye 4 times daily

Pediatric: Same as adults; safety and efficacy established for children aged 3 years and older

Geriatric: No specific dosage adjustment required; use with caution as with other medications

Renal Impairment: No specific dose adjustment required but monitor for efficacy and tolerability

Hepatic Impairment: No specific dose adjustment available

Pharmacokinetics

Absorption: Minimal systemic absorption from ocular administration

Distribution: Primarily localized to ocular tissues

Metabolism: Not extensively metabolized systemically

Excretion: Primarily via ocular tissues; systemic excretion details limited

Half Life: Data not well established, likely short due to topical use

Contraindications

• Hypersensitivity to pemirolast or any component of the formulation

Precautions

• Use cautiously in patients with active ocular infections or injuries; inform patients about potential allergenic reactions.

Adverse Reactions - Common

• Ocular discomfort, burning, or stinging (Common)
• Blurred vision (Uncommon)

Adverse Reactions - Serious

• Eye pain, swelling, or tearing (Rare)
• Anaphylaxis (extremely rare) (Very rare)

Drug-Drug Interactions

N/A

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Patient/Family Teaching

• Use medication exactly as prescribed.
• Avoid touching the dropper tip to eyes or other surfaces.
• Report any signs of adverse reactions such as persistent eye pain, swelling, or vision changes.
• Notify healthcare provider if symptoms worsen or do not improve within the expected time frame.

Special Considerations

Black Box Warnings: N/A

Genetic Factors: None known

Lab Test Interference: No significant interference reported in laboratory tests.

Overdose Management

Signs/Symptoms: Ocular irritation, redness, or systemic allergic reactions (rare).

Treatment: Wash the eyes with water; seek medical attention if symptoms are severe or persist.

Storage and Handling

Storage: Store at room temperature, away from moisture and light.

Stability: Stable when stored properly; check expiration date regularly.