Home Drug Guide Pyrithione Zinc

Drug Guide

Generic Name

Pyrithione Zinc

Brand Names Head & Shoulders Conditioner

Classification

Therapeutic: Antidandruff agent

Pharmacological: Zinc pyrithione (antifungal and antibacterial)

FDA Approved Indications

Dandruff
Seborrheic dermatitis

Mechanism of Action

Pyrithione zinc acts by disrupting the microbial cell membrane, resulting in inhibition of fungal and bacterial growth, leading to relief from dandruff and seborrheic dermatitis.

Dosage and Administration

Adult: Apply to wet scalp, massage, and rinse. Use as directed, typically several times per week.

Pediatric: Use as directed for children over age 2; consult health professional for specific instructions.

Geriatric: No specific adjustments necessary; monitor for skin sensitivity.

Renal Impairment: No specific dosage adjustment needed.

Hepatic Impairment: No specific dosage adjustment needed.

Pharmacokinetics

Absorption: Minimal absorption through the skin.

Distribution: Local action at the scalp.

Metabolism: Not significantly metabolized systemically.

Excretion: Excreted primarily in the feces.

Half Life: Not applicable due to minimal systemic absorption.

Contraindications

Hypersensitivity to zinc pyrithione or any ingredient in the formulation.

Precautions

Avoid contact with eyes. Discontinue use if irritation or allergic reactions occur. For external use only.

Adverse Reactions - Common

Scalp irritation (Uncommon)
Dryness or oiliness of the scalp (Uncommon)

Adverse Reactions - Serious

Allergic contact dermatitis (Rare)
Severe scalp irritation or swelling (Rare)

Drug-Drug Interactions

N/A

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Monitor scalp and skin for signs of irritation or allergic reaction.

Diagnoses:

Impaired skin integrity
Risk for allergic skin reaction

Implementation: Educate patient on proper application and frequency. Observe for adverse reactions.

Evaluation: Determine effectiveness by reduction in dandruff and improvement in scalp condition.

Patient/Family Teaching

Use as directed, do not overuse.
Avoid contact with eyes.
Report any signs of allergic reaction or scalp irritation.

Special Considerations

Black Box Warnings:

None.

Genetic Factors: None known.

Lab Test Interference: Minimal systemic absorption, unlikely to interfere with blood tests.

Overdose Management

Signs/Symptoms: Overuse may cause scalp irritation, dryness, or irritation.

Treatment: Discontinue use. Symptomatic treatment for scalp irritation. No need for systemic antidotes.

Storage and Handling

Storage: Store at room temperature, away from heat and moisture.

Stability: Stable under recommended conditions.