Home Drug Guide Sofpironium Bromide

Drug Guide

Generic Name

Sofpironium Bromide

Brand Names Sofdra

Classification

Therapeutic: Topical Anticholinergic (used for hyperhidrosis)

Pharmacological: Muscarinic receptor antagonist

FDA Approved Indications

  • Treatment of primary axillary hyperhidrosis (excessive underarm sweating)

Mechanism of Action

Sofpironium bromide inhibits muscarinic receptors in the eccrine sweat glands, reducing sweating.

Dosage and Administration

Adult: Apply a thin layer to affected areas once daily, as directed by the healthcare provider.

Pediatric: Use in children has not been established; consult specific guidelines.

Geriatric: Adjustments not typically required, but monitor for anticholinergic side effects.

Renal Impairment: Use with caution; no specific adjustments established.

Hepatic Impairment: Use with caution; limited data available.

Pharmacokinetics

Absorption: Minimal systemic absorption with topical application.

Distribution: Primarily localized; systemic levels are low.

Metabolism: Metabolized locally; systemic metabolism data limited.

Excretion: Excreted mainly unchanged in sweat and possibly via renal routes in minimal amounts.

Half Life: Data not widely published; likely short due to minimal systemic absorption.

Contraindications

  • Hypersensitivity to sofironium bromide or other anticholinergic agents.

Precautions

  • Use with caution in patients with urinary retention, close-angle glaucoma, or at risk for these conditions.
  • Avoid contact with eyes.

Adverse Reactions - Common

  • Dry skin or skin irritation at application site (Common)
  • Eyes irritation if contact occurs (Uncommon)

Adverse Reactions - Serious

  • Eye pain or visual disturbances (Rare)
  • Allergic skin reactions (Rare)

Drug-Drug Interactions

  • Little known systemic interactions due to minimal absorption.

Drug-Food Interactions

  • No significant interactions known.

Drug-Herb Interactions

  • No data available.

Nursing Implications

Assessment: Assess areas of hyperhidrosis before and after treatment.

Diagnoses:

  • Excessive skin moisture
  • Potential for skin irritation

Implementation: Apply as directed, with clean, dry skin.

Evaluation: Monitor reduction in sweating and skin tolerance.

Patient/Family Teaching

  • Apply only to affected areas as directed.
  • Avoid contact with eyes.
  • Report any skin irritation or eye discomfort.
  • Use regularly for optimal results.

Special Considerations

Black Box Warnings:

  • No black box warnings reported.

Genetic Factors: No specific genetic considerations.

Lab Test Interference: No known interference with lab tests.

Overdose Management

Signs/Symptoms: Potential systemic anticholinergic effects such as dry mouth, urinary retention, blurred vision, tachycardia.

Treatment: Discontinue use; symptomatic and supportive care. Specific antidote is not established.

Storage and Handling

Storage: Store at room temperature, away from moisture and light.

Stability: Stable under recommended storage conditions.

🛡️ 5 Critical Medication Safety Tips for Nurses

1

Triple-Check High-Risk Medications

Always have another nurse verify insulin, heparin, warfarin, and chemotherapy drugs. These "high-alert" medications cause the most serious errors. Check concentration, dose calculation, and pump settings twice.

2

Know Look-Alike, Sound-Alike Drugs

Common mix-ups: hydromorphone/morphine, Celebrex/Celexa, Zyprexa/Zyrtec. Always use BOTH generic and brand names, read labels twice, and use barcode scanning when available. One wrong letter can be fatal.

3

Assess Before AND After Giving Meds

Check vitals before cardiac meds, pain levels before analgesics, and blood glucose before insulin. Always reassess within 30 minutes to evaluate effectiveness and watch for adverse reactions.

4

Watch for Drug Interactions

Common dangerous combinations: warfarin + aspirin (bleeding), ACE inhibitors + potassium (hyperkalemia), digoxin + diuretics (toxicity). Always check drug interactions before administering new medications.

5

Educate Your Patients

Teach patients medication names, purposes, major side effects, and what to report. Informed patients catch errors and improve compliance. Always encourage questions - an educated patient is a safer patient.

⚡ Remember: When in doubt, don't give it out! It's always safer to double-check than regret later.

⚠️ Medical Disclaimer

This drug guide is for educational purposes only and is NOT intended for clinical use. Always consult current prescribing information, healthcare providers, and institutional protocols before administering any medication. Do not use this information for patient care decisions.