Nurses Compass
Drug Guide
Sulconazole Nitrate
Classification
Therapeutic: Antifungal
Pharmacological: Imidazole antifungal
FDA Approved Indications
- Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)
Mechanism of Action
Sulconazole inhibits fungal cytochrome P450 enzymes, impairing ergosterol synthesis. This disruption in ergosterol synthesis compromises fungal cell membrane integrity, leading to cell death.
Dosage and Administration
Adult: Apply a thin layer to affected skin twice daily for 2 weeks.
Pediatric: Use as directed by a healthcare provider; safety and efficacy in children have not been established.
Geriatric: Adjust dose only if renal or hepatic impairment occurs; no specific dose adjustment required.
Renal Impairment: No specific adjustment necessary, but monitor for toxicity.
Hepatic Impairment: Use with caution; no specific dosage adjustment established.
Pharmacokinetics
Absorption: Minimal systemic absorption when applied topically.
Distribution: Remain largely localized in the skin.
Metabolism: Metabolized minimally; primarily remains at site of application.
Excretion: Excreted primarily in the skin; systemic excretion negligible.
Half Life: Not typically applicable due to topical use; systemic half-life not well-defined.
Contraindications
- Hypersensitivity to sulconazole or other imidazole antifungals.
Precautions
- Use with caution in patients with sensitive skin or known allergies to azole antifungals; avoid contact with eyes, mucous membranes, and open wounds.
Adverse Reactions - Common
- Skin irritation (redness, itching, burning) (Uncommon)
- Dry skin (Uncommon)
Adverse Reactions - Serious
- Allergic contact dermatitis (Rare)
- Serious skin reactions (rare) (Rare)
Drug-Drug Interactions
- None well-documented with topical use.
Drug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Assess area for signs of infection and monitor for adverse reactions.
Diagnoses:
- Impaired skin integrity related to skin irritation or allergic reaction.
Implementation: Apply as directed, ensuring skin is clean and dry before application. Educate patient on proper topical application and hygiene.
Evaluation: Monitor skin condition and patient comfort during and after treatment.
Patient/Family Teaching
- Keep the affected area clean and dry.
- Apply medication as directed; do not overuse.
- Report signs of skin irritation or allergic reaction.
- Avoid contact with eyes, mouth, and broken skin.
Special Considerations
Black Box Warnings:
- None currently issued.
Genetic Factors: No known genetic factors influencing its use.
Lab Test Interference: Minimal systemic absorption means unlikely to interfere with lab tests.
Overdose Management
Signs/Symptoms: Excessive topical application may cause increased local irritation.
Treatment: Discontinue use; treat symptomatically, and seek medical attention if systemic symptoms develop.
Storage and Handling
Storage: Store at room temperature (20°C to 25°C), away from moisture and heat.
Stability: Stable under recommended storage conditions for specified shelf life.