Home Drug Guide Amino Acids (various formulations)

Drug Guide

Generic Name

Amino Acids (various formulations)

Brand Names Freamine 8.5%, Freamine II 8.5%, Freamine III 8.5%, Freamine III 10%, Freamine Hbc 6.9%, Travasol 5.5% W/o Electrolytes, Travasol 8.5% W/o Electrolytes, Travasol 10% W/o Electrolytes, Renamin W/o Electrolytes, Aminosyn 5%, Aminosyn 7%, Aminosyn 10%, Aminosyn 8.5%, Aminosyn 7% (ph6), Aminosyn 8.5% (ph6), Aminosyn 10% (ph6), Nephramine 5.4%, Aminosyn 3.5%, Novamine 8.5%, Novamine 11.4%, Novamine 15%, Aminosyn-rf 5.2%, Hepatamine 8%, Branchamin 4%, Branchamin 4% In Plastic Container, Neopham 6.4%, Aminosyn 3.5% In Plastic Container, Aminess 5.2% Essential Amino Acids W/ Histadine, Travasol 5.5% In Plastic Container, Travasol 8.5% In Plastic Container, Travasol 10% In Plastic Container, Trophamine, Trophamine 10%, Aminosyn-hbc 7%, Aminosyn-pf 7%, Aminosyn-hbc 7% In Plastic Container, Aminosyn Ii 3.5%, Aminosyn Ii 5%, Aminosyn Ii 7%, Aminosyn Ii 8.5%, Aminosyn Ii 10%, Aminosyn Ii 3.5% In Plastic Container, Aminosyn-pf 10%, Aminosyn Ii 10% In Plastic Container, Aminosyn Ii 15% In Plastic Container, Novamine 15% Sulfite Free In Plastic Container, Aminosyn-hf 8%, Hepatasol 8%, Clinisol 15% Sulfite Free In Plastic Container, Prosol 20% Sulfite Free In Plastic Container, Premasol 6% In Plastic Container, Premasol 10% In Plastic Container

Classification

Therapeutic: Nutritional Support

Pharmacological: Amino Acid Mixture

FDA Approved Indications

Parenteral nutrition in patients requiring amino acid supplementation
Supporting metabolic needs when oral nutrition is not feasible

Mechanism of Action

Provides essential and non-essential amino acids directly into the bloodstream, supporting protein synthesis and metabolic functions.

Dosage and Administration

Adult: Dose varies based on nutritional needs; typically 0.8-2.0 g amino acids/kg/day via IV infusion.

Pediatric: Dosed according to age and weight; commonly 0.5-2 g/kg/day under medical supervision.

Geriatric: Adjusted based on renal and hepatic function; require careful monitoring.

Renal Impairment: Dose adjustments required; monitor renal function and electrolytes.

Hepatic Impairment: Use with caution; avoid in hepatic encephalopathy unless monitored closely.

Pharmacokinetics

Absorption: Not applicable (administered parenterally).

Distribution: Distributed throughout body water compartments.

Metabolism: Metabolized in tissues; catabolized in liver or peripherally as proteins.

Excretion: Excreted mainly via urine as nitrogenous waste.

Half Life: Varies depending on the specific formulation and patient condition.

Contraindications

Allergy to amino acids or components
Metabolic disorders contraindicating amino acid infusion

Precautions

Monitor renal and hepatic function during therapy
Use caution in patients with fluid overload or electrolyte abnormalities
Pregnancy and lactation: consult specific product labeling

Adverse Reactions - Common

Pain or phlebitis at infusion site (Rare)
Electrolyte disturbances (Uncommon)

Adverse Reactions - Serious

Anaphylaxis (Rare)
Metabolic disturbances, including azotemia (Uncommon)

Drug-Drug Interactions

May interact with medications affecting renal or hepatic function
Certain alkali solutions may interact with amino acid infusions

Drug-Food Interactions

N/A

Drug-Herb Interactions

N/A

Nursing Implications

Assessment: Monitor infusion site, fluid status, electrolyte levels, and liver/kidney function.

Diagnoses:

Risk for electrolyte imbalance
ineffective tissue perfusion related to infusion complications

Implementation: Administer as prescribed, rotate infusion site, and monitor patient response.

Evaluation: Assess nutritional status, laboratory parameters, and infusion site regularly.

Patient/Family Teaching

Report any pain, swelling, or redness at infusion site immediately.
Understand that this is for nutritional support and will be given intravenously.
Follow instructions regarding infusion timing and monitoring.

Special Considerations

Black Box Warnings: N/A

Genetic Factors: None specified.

Lab Test Interference: May affect nitrogen balance tests and serum protein levels.

Overdose Management

Signs/Symptoms: Electrolyte imbalance, fluid overload, metabolic disturbances.

Treatment: Discontinue infusion, supportive care, correct electrolytes and fluid status.

Storage and Handling

Storage: Store in a cool, dry place; protect from light.

Stability: Stable until expiration date when unopened; follow specific product guidelines.